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Thirty male C57BL/6J mice (5 weeks old) were fed a high-fat diet (45% fat) for 8 weeks to induce obesity

Abstract Pain and depression are leading causes of disability and of profound social and economic burden

Clinical-only baseline modeling To quantify the incremental predictive value of metabolomics beyond baseline clinical features, a comparator survival model was trained using only clinical variables with randomForestSRC (v.3.3.1)

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Autism symptom severity was assessed using the Childhood Autism Rating Scale (CARS), a validated behavioral rating instrument [25]